Publications
NMR Staff Publications
The NMR facility supports a diverse range of chemical research across the department and beyond, with the NMR facility staff contributing to numerous research projects that result in journal publications.
They have extensive combined experience in the application of NMR spectroscopy to problems in synthetic organic, inorganic, and organometallic chemistry, peptides, oligosaccharides, protein-ligand interactions, solid-state NMR and more and are always happy to discuss how NMR can best support your research projects.
The year lists include publications involving NMR staff produced over the past decade.
Impact of Multiple Hydrogen Bonds with Fluoride on Catalysis: Insight from NMR Spectroscopy
Francesco Ibba, Gabriele Pupo, John M. Brown, Timothy D. W. Claridge, and Véronique Gouverneur, J. Am. Chem. Soc., 2020, 142, (46), 19731-19744 [DOI: 10.1021/jacs.0c09832]
Methyl gallate – rich fraction of Syzygium coriaceum Bosser & Guého leaf extract induced cancer cell cytotoxicity via oxidative stress.
Nawraj Rummun, Elisabete Pires, James McCullagh, Timothy W.D. Claridge, Theeshan Bahorun, Wen-Wu Li, Vidushi S. Neergheen-Bhujun, South African Journal of Botany, 2021, 137, 149-158. [DOI: 10.1016/j.sajb.2020.10.014]
Terminalia bentzoë, a Mascarene Endemic Plant, Inhibits Human Hepatocellular Carcinoma Cells Growth In Vitro via G0/G1 Phase Cell Cycle Arrest.
Nawraj Rummun, Philippe Rondeau, Emmanuel Bourdon, Elisabete Pires, James McCullagh, Timothy D. W. Claridge, Theeshan Bahorun, Wen-Wu Li, and Vidushi S. Neergheen. Pharmaceuticals, 2020, 13, 303, [DOI:10.3390/ph13100303]
Post-inflammatory behavioural despair in male mice is associated with reduced cortical glutamate-glutamine ratios, and circulating lipid and energy metabolites.
Shi Yu Chan, Fay Probert, Jennifer C Hebert, Timothy DW Claridge, Daniel C Anthony, Philip WJ Burnet, Scientific Reports, 2020, 10, 16857 [DOI: 10.1038/s41598-020-74008-w]
A blood‑based metabolomics test to distinguish relapsing–remitting and secondary progressive multiple sclerosis: addressing practical considerations for clinical application.
Tianrong Yeo, Megan Sealey, Yifan Zhou, Luisa Saldana, Samantha Loveless, Timothy D. W. Claridge, Neil Robertson, Gabriele DeLuca, Jacqueline Palace, Daniel C. Anthony & Fay Probert, Sci. Rep., 2020, 10, 12381 [DOI: 10.1038/s41598-020-69119-3]
Reducing agent mediated non-enzymatic conversion of 2-oxoglutarate to succinate – implications for oxygenase assays.
Amjad Khan, Christopher J. Schofield, and Timothy D. W. Claridge, ChemBioChem, 2020, 21, 2898-2902 [DOI: 10.1002/cbic.202000185]
The whole-cell Ca2+ release-activated Ca2+ current ICRAC, is regulated by the mitochondrial CA2+ uniporter channel and is independent of extracellular and cytosolic Na.
Krishna Samanta, Daniel Bakoswki, Nader Amin, and Anant B. Parekh, J. Physiol., 2020, 598, 1753-1773 [DOI: 10.1113/JP276551]
NMR waterLOGSY as An Assay in Drug Development Programmes for Detecting Protein-Ligand Interactions–NMR waterLOGSY.
Carole J. R. Bataille, Terence H. Rabbitts, and Timothy D. Claridge, Bio-protocol 10(13): e3666. [DOI: 10.21769/BioProtoc.3666]
Monitoring protein-metal binding by 19F NMR – Case study with the New Delhi metallo-β-lactamase 1.
Anna M. Rydzik, Jürgen Brem, Timothy D. W. Claridge, and Christopher J. Schofield, RSC Med. Chem., 2020,11, 387-391 [DOI: 10.1039/c9md00416e]
Global Aromaticity at the Nanoscale
Michel Rickhaus, Michael Jirasek, Lara Tejerina, Henrik Gotfredsen, Martin D. Peeks, Renée Haver, Hua-Wei Jiang, Timothy D. W. Claridge, and Harry L. Anderson, Nat. Chem., 2020, 12, 236–241 [DOI: 10.1038/s41557-019-0398-3]
Studies on the Selectivity of Proline Hydroxylases Reveal New Substrates Including Bicycles
Tristan J. Smart, Refaat B. Hamed, Timothy D. W. Claridge, Christopher J. Schofield, Bioorganic Chemistry, 2020, 94 103386 [DOI: 10.1016/j.bioorg.2019.103386]
Global Aromaticity and Antiaromaticity in Porphyrin Nanoring Anions.
Martin D. Peeks, Michael Jirasek, Timothy D. W. Claridge and Harry L. Anderson, Angew. Chem. Int. Ed., 2019, [DOI: 10.1002/anie.201909032]
New NOAH Modules for Structure Elucidation at Natural Isotopic Abundance.
Ēriks Kupče and T. D. W. Claridge, J. Magn. Reson., 2019, [DOI: 10.1016/j.jmr.2019.106568]
19F-NMR Monitoring of Reversible Protein Post-Translational Modifications: Class D β-Lactamase Carbamylation and Inhibition.
Emma van Groesen, Christopher T. Lohans, Jürgen Brem, Kristina M. J. Aertker, Timothy D. W. Claridge, and Christopher J. Schofield., Chem. Eur. J., 2019, [DOI: 10.1002/chem.201902529]
Triplet NOAH supersequences optimised for small molecule structure characterisation.
Tim D. W. Claridge, Maksim Mayzel, and Ēriks Kupče, Magn. Reson. Chem., 2019, [DOI:10.1002/mrc.4887]
Electrochemical Oxidation of the Phospha- and Arsa-ethynolate Anions, PCO– and AsCO–
Frank Tambornino, Eden E. L. Tanner, Hatem M. A. Amin, Jennifer Holter, Tim Claridge, Richard G. Compton, and Jose M. Goicoechea, Eur. J. Inorg. Chem., 2019, 1644–1649 [DOI: 10.1002/ejic.201801503]
Biocatalytic Production of Bicyclic β-Lactams with Three Contiguous Chiral Centres using Engineered Crotonases.
Refaat Hamed, Ruben Gomez-Castellanos, Luc Henry, Sven Warhaut, Timothy D. W. Claridge, and Christopher Schofield, Nature Comms. Chem., 2019, 2:7 [DOI: 10.1038/s42004-018-0106-z]
Classifying the antibody negative NMO syndromes: clinical, imaging and metabolomic modeling.
Tianrong Yeo, Fay Probert, Maciej Jurynczyk, Megan Sealey, Ana Cavey, Tim D. W. Claridge, Mark R Woodhall, Patrick J. Waters, Maria Isabel S. Leite, Daniel Anthony, and Jacqueline Palace, , Neurol Neuroimmunol Neuroinflamm 2019, 6, e626. [DOI:10.1212/NXI.0000000000000626]
Isolation, structural identification, synthesis, and pharmacological profiling of 1,2-trans-dihydro-1,2-diol metabolites of the utrophin modulator ezutromid.
Maria Chatzopoulou, Tim D. W. Claridge, Kay E. Davies, Stephen G. Davies, David Elsey, Enrico Emer, Ai M. Fletcher, Shawn Harriman, Neil Robinson, Jessica Rowley, Angela J. Russell, Jonathan Tinsley, Richard Weaver, Isabel Wilkinson, Nicky Willis, Francis Wilson, and Graham M. Wynne, J. Med. Chem. 2019, [DOI: 10.1021/acs.jmedchem.9b01547]
19F NMR studies on γ-Butyrobetaine Hydroxylase Provide Mechanistic Insights and suggest a dual Inhibition mode.
Robert K. Leśniak, Anna M. Rydzik, Jos J. A. G. Kamps, Amjad Kahn, Timothy D. W. Claridge, and Christopher J. Schofield, Chem. Comm, 2019, 55, 14717-14720 [DOI: 10.1039/C9CC06466D]
How formaldehyde reacts with amino acids.
Jos J. A. G. Kamps, Richard J. Hopkinson, Christopher J. Schofield, and Timothy D. W. Claridge, Commun Chem, 2019, 2, 126 [DOI: 10.1038/s42004-019-0224-2]
Reliable, high-quality suppression of NMR signals arising from water and macromolecules: application to bio-fluid analysis.
Juan A. Aguilar, Julia Cassani, Fay Probert, Jacqueline Palace, Tim D. W. Claridge, Adolfo Botana and Alan M. Kenwright, Analyst, 2019, 144, 7270 - 7277 [DOI: 10.1039/C9AN01005J]
Studies on the Substrate Selectivity of the Hypoxia‐Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain.
Martine I. Abboud, Rasheduzzaman Chowdhury, Ivanhoe K.H. Leung, Kerstin Lippl, Christoph Loenarz, Timothy D.W. Claridge, and Christopher J. Schofield, ChemBioChem, 2018, 19, 2262-2267 [DOI: 10.1002/cbic.201800246]
Plasma Nuclear Magnetic Resonance Metabolomics Discriminates Between High and Low Endoscopic Activity and Predicts Progression in a Prospective Cohort of Patients With Ulcerative Colitis.
Fay Probert, Alissa Walsh, Marta Jagielowicz, Tianrong Yeo, Timothy D. W. Claridge, Alison Simmons, Simon Travis, Daniel C Anthony, Journal of Crohn's and Colitis, 2018, 12, 1326–1337 [DOI: 10.1093/ecco-jcc/jjy101]
Human histone demethylase KDM6B can catalyse sequential oxidations.
Richard J. Hopkinson, Gareth W. Langley, Roman Belle, Louise J. Walport, Kate Dunne, Martin Münzel, Eidarus Salah, Akane Kawamura, Timothy D. W. Claridge and Christopher J. Schofield, Chem. Comm. 2018, 54, 7975-7978 [DOI: 10.1039/c8cc04057e]
The Dimroth rearrangement as a probable cause for structure mis-assignments in imidazo[1,2-a]pyrimidines: A 15N-labelling study and an easy method for the determination of regio-chemistry.
Maria Chatzopoulou, Fernando Martinez Vasquez, Nicky J. Willis, Timothy D. W. Claridge, Francis X. Wilson, Graham M. Wynne, Stephen G. Davies, Angela J. Russell, Tetrahedron, 2018, 38, 5280-5288 [DOI: 10.1016/j.tet.2018.06.033]
Molecular Structure from a Single NMR Supersequence.
Eriks Kupce and Tim D. W. Claridge, Chem. Comm., 2018, 54, 7139-7142 [DOI: 10.1039/C8CC03296C]
NMR Analyses on N-Hydroxymethylated Nucleobases – Implications for Formaldehyde Toxicity and Nucleic Acid Demethylases.
S. Shishodia, D. Zhang, A. El-Sagheer, T. Brown, T. D. W. Claridge, C. J. Schofield and R. J. Hopkinson, Org. Biomol. Chem. 2018, 16, 4021-4032 [DOI: 10.1039/c8ob00734a]
Non-competitive cyclic peptides for targeting enzyme-substrate complexes.
Tom E McAllister, Tzu-Lan Yeh, Martine I Abboud, Ivanhoe K H Leung, Edward S Hookway, Oliver N F King, Bhaskar Bhushan, Sophie T Williams, Richard J. Hopkinson, Martin Münzel, Nikita Loik, Rasheduzzaman Chowdhury, Udo Oppermann, Timothy D. W. Claridge, Yuki Goto, Hiroaki Suga, Christopher J. Schofield & Akane Kawamura, Chemical Science, 2018, 9, 4569-4578 [DOI: 10.1039/C8SC00286J]
NMReDATA, a standard to report the NMR assignment and parameters of organic compounds.
Marion Pupier, Jean-Marc Nuzillard, Julien Wist, Nils E. Schlörer, Stefan Kuhn, Mate Erdelyi, Christoph Steinbeck, Antony J. Williams, Craig Butts, Tim D. W. Claridge, Bozhana Mikhova, Wolfgang Robien, Hesam Dashti, Hamid R. Eghbalnia, Christophe Farès, Christian Adam, Kessler Pavel, Fabrice Moriaud, Mikhail Elyashberg, Dimitris Argyropoulos, Manuel Pérez, Patrick Giraudeau, Roberto R. Gil, Paul Trevorrow, Damien Jeannerat, Magn. Reson. Chem., 2018, , 56, 703-715 [DOI: 10.1002/mrc.4737]
Synthesis of statistical PET/PEN random block copolymers and their crystallizability in the bulk and at the surface.
Kei Shinotsuka, Hazel Assender, and Timothy D. W. Claridge Journal of Applied Polymer Science, 2018, 135, 46515 [DOI: 10.1002/app.46515]
Measuring Spin Relaxation Rates using Satellite Exchange NMR Spectroscopy.
Gerard P. Robertson, Barbara Odell, Ilya Kuprov, Darren J. Dixon, and Tim D. W. Claridge, Angew. Chem. Int. Ed., 2018, , 57, 7498-7502 [DOI: 10.1002/anie.201801322]
Template-Directed Synthesis of a Conjugated Zinc Porphyrin Nanoball.
Jonathan Cremers, Renee Haver, Michel Rickhaus, Juliane Q. Gong, Ludovic Favereau, Martin D. Peeks, Tim D. W. Claridge, Laura M. Herz, and Harry L. Anderson, J. Am. Chem. Soc., 2018, 140, 5352-5355. [DOI: 10.1021/jacs.8b02552]
Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells.
Fidelia Ijeoma Uche, James McCullagh, Timothy W.D. Claridge, Alan Richardson, Wen-Wu Li, Bioorg. Med. Chem. Lett., 2018, 28, 1652–1656 [DOI: 10.1016/j.bmcl.2018.03.038]
On the ozonolysis of unsaturated tosylhydrazones as a direct approach to diazocarbonyls.
Younes Fegheh-Hassanpour, Faisal Ebrahim, Tanzeel Arif, Herman O. Sintim, Timothy D. W. Claridge, Nader T. Amin and David M. Hodgson, Org. Biol. Chem., 2018, 16, 2876-2884. [DOI: 10.1039/C8OB00435H]
2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.
Martine I. Abboud, Tom E. McAllister, Ivanhoe K. H. Leung, Rasheduzzaman Chowdhury, Christian Jorgensen, Carmen Domenea, Jasmin Mecinović, Kerstin Lippl, Rebecca L. Hancock, Richard J. Hopkinson, Akane Kawamura, Timothy D. W. Claridge and Christopher J. Schofield, Chem. Commun., 2018, 54, 3130-3133 [DOI: 10.1039/C8CC00387D]
Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis.
Martine I. Abboud, Magda Kosmopoulou, Anthony P. Krismanich, Jarrod W. Johnson, Philip Hinchliffe, Jurgen Brem,
Timothy D. W. Claridge, James Spencer, Christopher J. Schofield, and Gary I. Dmitrienko, Chem. Eur. J. 2018, 24, 5734-5737 [DOI: 10.1002/chem.201705886]
The efficacy of the Quercetin analogue LY294002 in immortalized cancer cell lines is related to the oxygenic and metabolic status of cells.
Xinyue Huang, Michelle Potter, Ben Pilgrim, Ruchuta Ardkhean, Mikail Kabeshov, Timothy Claridge, Matthew Wiseman, Karl Jonathan Morten, Timothy Donohoe, Helen Elizabeth Townley, Int J Cancer Ther Oncol. 2017; 5(1):51X. [DOI: 10.14319/ijcto.51.14]
Metabolomics reveals distinct, antibody-independent, molecular signatures of MS, AQP4-antibody and MOG-antibody disease
Maciej Jurynczyk, Fay Probert, Tianrong Yeo, George Tackley, Tim D.W. Claridge, Ana Cavey, Mark R. Woodhall, Siddharth Arora, Torsten Winkler, Eric Schiffer, Angela Vincent, Gabriele DeLuca, Nicola R. Sibson, M. Isabel Leite, Patrick Waters, Daniel C Anthony, and Jacqueline Palace.
Acta Neuropathologica Communications, 2017, 5:95 [DOI: 10.1186/s40478-017-0495-8]
Single-Acetylene Linked Porphyrin Nanorings
Michel Rickhaus, Andreas Vargas Jentzsch, Lara Tejerina, Isabell Grübner, Michael Jirasek, Timothy D. W. Claridge, and Harry L. Anderson,
J. Am. Chem. Soc., 2017, 139, 16502−16505 [DOI: 10.1021/jacs.7b10710]
Terminally truncated isopenicillin N synthase generates a dithioester product: evidence for a thioaldehyde intermediate during catalysis and a new mode of reaction for non-heme iron oxidases.
Luke A. McNeill Toby J. N. Brown, Malkit Sami, Ian J. Clifton, Nicolai I. Burzlaff, Timothy D. W. Claridge, Robert M. Adlington, Jack E. Baldwin, Peter J. Rutledge, and Christopher J. Schofield.
Chem. Eur. J., 2017, 23, 12815-12824 [DOI: 10.1002/chem.201701592]
Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials.
Tzu-Lan Yeh, Thomas M. Leissing, Martine I. Abboud, Cyrille C. Thinnes, Onur Atasoylu, James P. Holt-Martyn, Dong Zhang, Anthony Tumber, Kerstin Lippl, Christopher T. Lohans, Ivanhoe K. H. Leung, Helen Morcrette, Ian. J. Clifton, Timothy D. W. Claridge, Akane Kawamura, Emily Flashman, Xin Lu, Peter J. Ratcliffe, Rasheduzzaman Chowdhury, Christopher W. Pugh, and Christopher J. Schofield.
Chemical Science, 2017, 8, 7651–7668 [DOI: 10.1039/c7sc02103h.]
Isochondodendrine and 2′-norcocsuline: additional alkaloids from Triclisia subcordata, induced cytotoxicity and apoptosis in ovarian cancer cell lines.
Fidelia Ijeoma Uche, Mohammed N. Abed, Marwan I. Abdullah, Falko P. Drijfhout, James McCullagh, Timothy W. D. Claridge, Alan Richardson and Wen-Wu Li.
RSC Adv., 2017, 7, 44154-44161 [DOI: 10.1039/c7ra08032h]
NOAH – NMR Supersequences for Small Molecule Analysis and Structure Elucidation.
Eriks Kupce and Tim D. W. Claridge.
Angew. Chem. Int. Ed., 2017, 56, 11779-11783 [DOI: 10.1002/anie.201705506]
mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation.
Anna M. Rydzik, Marcin Warminski, Pawel J. Sikorski, Marek R. Baranowski, Sylwia Walczak, Joanna Kowalska, Joanna Zuberek, Maciej Lukaszewicz, Elzbieta Nowak, Timothy D. W. Claridge, Edward Darzynkiewicz, Marcin Nowotny, Jacek Jemielity.
Nucleic Acid Research, 2017, 45, 8661–8675 [DOI: 10.1093/nar/gkx569]
AMP binding stabilizes the KTN domain of the Shewanella denitrificans Kef potassium efflux system.
Christos Pliotas, Samuel C. Grayer, Sylvia Ekkerman, Anthony K. N. Chan, Jessica Healy, Phedra Marius, Wendy Bartlett, Amjad Khan, Wilian A. Cortopassi, Shane A Chandler, Tim Rasmussen, Justin L. P. Benesch, Robert S. Paton, Tim D. W. Claridge, Samantha Miller, Ian R. Booth, James H. Naismith and Stuart J. Conway.
Biochemistry, 2017, 56, 4219-4234. [DOI: 10.1021/acs.biochem.7b00300]
13C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions.
Christopher T. Lohans, David Y. Wang, Christian Jorgensen, Samuel T. Cahill, Ian J. Clifton, Michael A. McDonough, Henry P. Oswin, James Spencer, Carmen Domene, Timothy D. W. Claridge, Jürgen Brem and Christopher J. Schofield.
Org. Biomol. Chem., 2017, 15, 6024-6032 [DOI: 10.1039/c7ob01514c]
Evaluation of 1H NMR metabolic profiling of Niemann Pick type 1 patient plasma as a potential diagnostic tool.
Fay Probert, Victor Ruiz-Rodado, Danielle te Vruchte, Elena-Raluca Nicoli, Tim D.W. Claridge, Christopher A. Wassif, Nicole Farhat, Forbes D. Porter, Frances M. Platt and Martin Grootveld.
Sci Reps. 2017, 7, 6320; [DOI: 10.1038/s41598-017-06264-2]
Mechanistic studies on a Cu-catalysed asymmetric allylic alkylation with cyclic racemic starting materials.
Emeline Rideau, Hengzhi You, Mireia Sidera, Timothy D. W. Claridge, Stephen P. Fletcher.
J. Am. Chem. Soc. 2017, 139, 5614−5624. [DOI: 10.1021/jacs.7b02440]
Monitoring the Disassembly of Virus-like Particles by 19F NMR.
Rogen L. C. Leung, Matthew D. M. Robinson, Alaa A. A. Ajabali, Gogulan Karunanithy, Brian Lyons, Ritu Raj, Saeed Raoufmoghaddam, Shabaz Mohammed, Timothy D. W. Claridge, Andrew J. Baldwin and Benjamin G. Davis.
J. Am. Chem. Soc. 2017, 139, 5277−5280. [DOI: 10.1021/jacs.6b11040]
19F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paolo Metallo-β-Lactamase.
Martine I. Abboud, Jürgen Brem, Philip Hinchliffe, Robert Macsics, Inga Pfeffer, Anne Makena, Klaus-Daniel Umland, Anna M. Rydzik, Guo-Bo Li, James Spencer, Timothy D.W. Claridge, and Christopher J. Schofield.
Angew. Chem. Int. Ed. 2017, 56, 3862 –3866. [DOI: 10.1002/anie.201612185]
Protein-ligand binding affinity determination by the waterLOGSY method: An optimised approach considering ligand rebinding.
Renjie Huang, Arnaud Bonnichon, Timothy D. W. Claridge, Ivanhoe K. H. Leung
Sci. Reps. 2017, 7, 43727; [DOI: 10.1038/srep43727]
Formation of a σ-alkane Complex and a Molecular Rearrangement in the Solid-State: [Rh(Cyp2PCH2CH2PCyp2)(η2:η2-C7H12)][BArF4]
Alasdair I. McKay, Tobias Krämer, Nicholas H. Rees, Amber L. Thompson, Kirsten E. Christensen, Stuart A. Macgregor, and Andrew S. Weller
Organometallics, 2017, 36, 22–25. [DOI: 10.1021/acs.organomet.6b00645]
A characterization of the antimalarial activity of the bark of Cylicodiscus gabunensis Harms.
Omar Aldulaimi, Fidelia I. Uche, Hamza Hameed, Haddijatou Mbye, Imran Ullah, Falko Drijfhout, Timothy D.W. Claridge, Paul Horrocks, Wen-Wu Li
Journal of Ethnopharmacology, 2017, 198, 221–225. [DOI: 10.1016/j.jep.2017.01.014]
Stereoselective Production of Dimethyl-Substituted Carbapenams via Engineered Carbapenem Biosynthesis Enzymes.
Refaat B. Hamed, Luc Henry, Timothy D. W. Claridge, and Christopher J. Schofield
ACS Catalysis, 2017, 7, 1279−1285. [DOI: 10.1021/acscatal.6b02509]
Aromatic and antiaromatic ring currents in a molecular nanoring.
Martin D. Peeks, Timothy D. W. Claridge, Harry L. Anderson
Nature, 2017, 541, 200-203. [DOI: 10.1038/nature20798]
Post-translational mutagenesis: A chemical synthetic strategy for exploration of protein side-chain diversity.
Tom H. Wright, Ben J. Bower, Justin M. Chalker, Gonçalo J. L. Bernardes, Rafal Wiewiora, Wai-Lung Ng, Ritu Raj, Sarah Faulkner, M. Robert J. Vallée, Anuchit Phanumartwiwath, Oliver D. Coleman, Marie-Laëtitia Thézénas, Maola Khan, Sébastien R. G. Galan, Lukas Lercher, Matthew W. Schombs, Stefanie Gerstberger, Maria E. Palm-Espling, Andrew J. Baldwin, Benedikt M. Kessler, Timothy D. W. Claridge, Shabaz Mohammed, Benjamin G. Davis,
Science, [DOI: 10.1126/science.aag1465]
Early diagnosis of brain metastases using a biofluids-metabolomics approach in mice.
James R. Larkin, Alex M. Dickens, Timothy D. W. Claridge, Claire Bristow, Kleopatra Andreou, Daniel C. Anthony, Nicola R. Sibson.
Theranostics, 2016, 6, 2161-2169 [DOI: 10.7150/thno.16538].
Torsional and Electronic Factors Control the C−H⋅⋅⋅O Interaction.
R. W. Driver, T. D. W. Claridge, S. Scheiner, M. D. Smith.
Chem. Eur. J. 2016, 22, 16513-16521. [DOI: 10.1002/chem.201602905]
Normal tissue radioprotection by amifostine via Warburg-type effects.
Michael I. Koukourakis, Alexandra Giatromanolaki, Christos E. Zois, Dimitra Kalamida, Stamatia Pouliliou, Ilias V. Karagounis, Tzu-Lan Yeh, Martine I. Abboud, Timothy D. W. Claridge, Christopher J. Schofield, Efthimios Sivridis, Costantinos Simopoulos, Savvas P. Tokmakidis and Adrian L. Harris.
Sci. Rep., 2016, 6, 30986. [DOI: 10.1038/srep30986]
Interaction of Avibactam with Class B Metallo-β-lactamases.
Martine I. Abboud, Christian Damblon, Jürgen Brem, Nicolas Smargiasso, Paola Mercuri, Bernard Gilbert, Anna M. Rydzik,Timothy D. W. Claridge, Christopher J. Schofield, and Jean-Marie Frère,
Antimicrob. Agents Chemother., 2016, 60, 5655–5662 [DOI:10.1128/AAC.00897-16]
Nanorings with Copper(II) and Zinc(II) Centers: Forcing Copper Porphyrins to Bind Axial Ligands in Heterometallated Oligomers.
Jonathan Cremers, Sabine Richert, Dmitry V. Kondratuk, Tim D. W. Claridge, Christiane R. Timmel, and Harry L. Anderson,
Chemical Science, 2016, 7, 6961-6968. [DOI: 10.1039/C6SC01809B]
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
Rasheduzzaman Chowdhury, Ivanhoe K. H. Leung, Ya-Min Tian, Martine I. Abboud, Wei Ge, Carmen Domene, François-Xavier Cantrelle, Isabelle Landrieu, Adam P. Hardy, Christopher W. Pugh, Peter J. Ratcliffe, Timothy D. W. Claridge & Christopher J. Schofield,
Nat. Commun. 2016, 7:12673, [DOI: 10.1038/ncomms12673].
Synthesis and Characterization of Solid Polymethylaluminoxane: A Bifunctional Activator and Support for Slurry-Phase Ethylene Polymerization
Kilpatrick, Alexander F. R.; Buffet, Jean-Charles; Noerby, Peter; Rees, Nicholas H.; Funnell, Nicholas P.; Sripothongnak, Saovalak; O'Hare, Dermo
Chemistry of Materials, 2016, 28, 7444-7450 [DOI: 10.1021/acs.chemmater.6b03009].
Substituent effects on fluoride binding by lanthanide complexes of DOTA-tetraamides
Blackburn, Octavia A.; Routledge, Jack D.; Jennings, Laura B.; Rees, Nicholas H.; Kenwright, Alan M.; Beer, Paul D.; Faulkner, Stephen
Dalton Transactions, 2016, 45, 3070-3077 [DOI: 10.1039/C5DT04349B].
Selective C-H Activation at a Molecular Rhodium Sigma-Alkane Complex by Solid/Gas Single-Crystal to Single-Crystal H/D Exchange
Chadwick, F. Mark; Kramer, Tobias; Gutmann, Torsten; Rees, Nicholas H.; Thompson, Amber L.; Edwards, Alison J.; Buntkowsky, Gerd; Macgregor, Stuart A.; Weller, Andrew S.
Journal of the American Chemical Society, 2016, 138, 13369-13378 [DOI: 10.1021/jacs.6b07968].
Hydrogen cleavage by solid-phase frustrated Lewis pairs
Xing, Jun-Yi; Buffet, Jean-Charles; Rees, Nicholas H.; Noerby, Peter; O'Hare, Dermot
Chemical Communications, 2016, 52, 10478-10481 [DOI: 10.1039/C6CC04937K].
Heptaphosphide cluster anions bearing group 14 element amide functionalities.
Quintero, Gabriela Espinoza; Paterson-Taylor, Isabelle; Rees, Nicholas H.; Goicoechea, Jose M.
Dalton Transactions, Volume: 45, Issue: 5, Pages: 1930-1936. [DOI: 10.1039/C5DT02380G].
Catalytic enantio- and diastereoselective Mannich reaction of α-substituted isocyanoacetates and ketimines
de la Campa, Raquel; Gammack Yamagata, Adam D.; Ortin, Irene; Franchino, Allegra; Thompson, Amber L.; Odell, Barbara; Dixon, Darren J
Chem. Commun., 2016, 52, 10632-10635 [DOI:10.1039/C6CC04132A].
Hydrogen Bonding to Hexafluoroisopropanol Controls the Oxidative Strength of Hypervalent Iodine Reagents
Colomer, Ignacio; Batchelor-McAuley, Christopher; Odell, Barbara; Donohoe, Timothy J.; Compton, Richard G
J. Am. Chem. Soc., 2016, 138, 8855-8861. [DOI:10.1021/jacs.6b04057]
Synthesis of Five-Porphyrin Nanorings by Using Ferrocene and Corannulene Templates
Liu, Pengpeng; Hisamune, Yutaka; Peeks, Martin D.; Odell, Barbara; Gong, Juliane Q.; Herz, Laura M.; Anderson, Harry L
Angew. Chem., Int. Edn, 2016, 55, 8358-8362. [DOI:10.1002/anie.201602909]
Scalar cross-relaxation detected in the NOESY spectra of Oxazolidines and Thiazolidines.
Tharindi D. Panduwawala, Laia Josa-Culleré, Ilya Kuprov, Barbara Odell, Mark G. Moloney, and Timothy D. W. Claridge.
J. Org. Chem. 2016, 81, 4142-4148 [DOI: 10.1021/acs.joc.6b00458]
Harnessing NMR relaxation interference effects to characterise supramolecular assemblies.
Gogulan Karunanithy, Arjen Cnossen, Henrik Müller, Martin D. Peeks, Nicholas H. Rees, Timothy D. W. Claridge, Harry L. Anderson and Andrew J. Baldwin.
Chem. Comm. 2016, 52, 7450-7453 [DOI: 10.1039/C6CC02544G]
Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.
Sook Y. Lee, Jürgen Brem, Ilaria Pettinati, Timothy D. W. Claridge, Opher Gileadi, Christopher J. Schofield and Peter J. McHugh.
Chem. Comm., 2016, 52, 6727-6730. [DOI: 10.1039/C6CC00529B]
Development and applications of an efficient NMR ligand-based binding assay for γ-butyrobetaine hydroxylase (BBOX).
Amjad Khan, Robert K. Lesniak, Anna M. Rydzik, Hwanho Choi, Ivanhoe K. H. Leung, Jürgen Brem, Michael A. McDonough, Christopher J. Schofield, and Timothy D. W. Claridge.
MedChemComm, 2016, 7, 873-880. [DOI: 10.1039/C6MD00004E]
A Rhodium–Pentane Sigma-Alkane Complex: Characterization in the Solid State by Experimental and Computational Techniques.
F. Mark Chadwick, Nicholas H. Rees, Andrew S. Weller, Tobias Krmer, Marcella Iannuzzi, and Stuart A. Macgregor.
Angew. Chem. Int. Ed., 2016, 55, 3677 –3681. [DOI: 10.1002/anie.201511269]
Synthesis and Characterization of a Novel N-F Reagent derived from the Ethano-Tröger’s Base: 1JFN Coupling Constant as Signature for the N-F Bond.
Raul Pereira, Jamie Wolstenhulme, Graham Sandford, Timothy D. W. Claridge, Véronique Gouverneur and Jan Cvengroš.
Chem. Comm, 2016, 52, 1606-1609. [DOI: 10.1039/C5CC08375C]
Core–shell zeolite@aqueous miscible organic-layered double hydroxides.
Chunping Chen , Coral F. H. Byles , Jean-Charles Buffet , Nicholas H. Rees , Yue Wu and Dermot O'Hare.
Chem. Sci., 2016, 7, 1457-1461 [DOI: 10.1039/C5SC03208C]
Urinary Excretion and Metabolism of Miglustat and Valproate in Patients with Niemann-Pick Type C1 Disease: One- and Two-Dimensional Solution-State 1H NMR Studies
Fay Probert, Victor Ruiz-Rodado, Xiaoyu Zhang, Danielle te Vruchte,Tim D.W. Claridge, Mark Edgar, Anna Zonato Tocchio, Robin H. Lachmann,Frances M. Platt, Martin Grootveld.
J. Pharm. Biomed. Anal., 2016, 117, 276–288. [DOI: 10.1016/j.jpba.2015.08.011]
Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1.
Jürgen Brem, Weston B. Struwe, Anna M. Rydzik, Hanna Tarhonskaya, Inga Pfeffer, Emily Flashman, Sander S. van Berkel, James Spencer, Timothy D. W. Claridge, Michael A. McDonough, Justin L. P. Benesch and Christopher J. Schofield
Chemical Science, 2015, 6, 956-963. [DOI: 10.1039/C4SC01752H]
Anomalous Nuclear Overhauser Effects in Carbon-Substituted Aziridines: Scalar Cross-Relaxation of the First Kind
Ilya Kuprov, David M. Hodgson, Johannes Kloesges, Christopher I. Pearson, Barbara Odell, and Timothy D. W. Claridge
Angew. Chem. Int. Ed. 2015, 54, 3697-3701. [DOI: 10.1002/anie.201410271]
Caterpillar Track Complexes in Template-Directed Synthesis and Correlated Molecular Motion
Shiqi Liu, Dmitry V. Kondratuk, Sophie A. L. Rousseaux, Guzmµn Gil-Ramírez, Melanie C. O’Sullivan, Jonathan Cremers, Tim D. W. Claridge, and Harry L. Anderson
Angew. Chem. Int. Ed. 2015, 54, 5355–5359 [DOI: 10.1002/anie.201412293]
Cerebrospinal fluid metabolomics implicate bioenergetic adaptation as a neural mechanism regulating shifts in cognitive states of HIV-infected patients.
A. M. Dickens, D. C. Anthony, R. Deutsch, M. M. Mielke, T. D. W. Claridge, I. Grant, D. Franklin, D. Rosario, T. Marcotte, S. Letendre, J. C. McArthur, N. J.Haughey
AIDS, 2015, 29, 559-569 [DOI: 10.1097/QAD.0000000000000580].
Fluorophosphate Nucleotide Analogs as Versatile Tools for 19F NMR Studies
Marek R. Baranowski, Anna Nowicka, Anna M. Rydzik, Marcin Warminski, Renata Kasprzyk, Blazej A. Wojtczak, Jacek Wojcik, Timothy D. W. Claridge, Joanna Kowalska, Jacek Jemielity
J. Org. Chem., 2015, 80, 3982-3997. [DOI: 10.1021/acs.joc.5b00337]
Potent and Selective Triazole-based Inhibitors of the Hypoxia-inducible Factor Prolyl-hydroxylases with Activity in the Murine Brain.
Mun Chiang Chan, Onur Atasoylu, Emma Hodson, Anthony Tumber, Ivanhoe K. H. Leung, Rasheduzzaman Chowdhury, Verónica Gómez-Pérez, Marina Demetriades, Anna M. Rydzik, James Holt-Martyn, Ya-Min Tian, Tammie Bishop, Timothy D. W. Claridge, Akane Kawamura, Christopher W. Pugh, Peter J. Ratcliffe, Christopher J. Schofield
PLoS ONE 10(7): e0132004. [DOI:10.1371/journal.pone.0132004]
The longitudinal cerebrospinal fluid metabolomic profile of amyotrophic lateral sclerosis
Elizabeth Gray, James R. Larkin, Tim D. W. Claridge, Kevin Talbot, Nicola R. Sibson, and Martin R. Turner
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2015, 1-8. [DOI:10.3109/21678421.2015.105349]
NMR-Based Metabolomics Separates the Distinct Stages of Disease in a Chronic Relapsing Model of Multiple Sclerosis.
Alex M. Dickens, James R. Larkin, Benjamin G. Davis, Julian L. Griffin, Timothy D. W. Claridge, Nicola R. Sibson, Daniel C. Anthony
J. Neuroimmune Pharmacol., 2015, 10, 435-444. [DOI: 10.1007/s11481-015-9622-0]
The Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor N-oxalylglycine is present in Rhubarb and Spinach Leaves.
Khalid Al-Qahtani, Bushra Jabeen, Rok Sekirnik, Naheed Riaz, Timothy D.W. Claridge, Christopher J. Schofield, James S.O. McCullagh
Phytochemistry, 2015, 117, 456-461. [DOI: 10.1016/j.phytochem.2015.06.028]
α- and α′-Lithiation−Electrophile Trapping of N-Thiopivaloyl and N-tert-Butoxythiocarbonyl α-Substituted Azetidines: Rationalization of the Regiodivergence Using NMR and Computation.
Kelvin E. Jackson, Claire L. Mortimer, Barbara Odell, Jeffrey M. McKenna, Timothy D. W. Claridge, Robert S. Paton, and David M. Hodgson
J. Org. Chem., 2015, 80, 9838-9846. [DOI: 10.1021/acs.joc.5b01804]
Barrierless Photoisomerization of 11-cis Retinal Protonated Schiff Base in Solution
Giovanni Bassolino, Tina Sovdat, Alex Soares Duarte, Jong Min Lim, Christoph Schnedermann, Matz Liebel, Barbara Odell, Timothy D.W. Claridge, Stephen P. Fletcher, Philipp Kukura
J. Am. Chem. Soc., 2015, 137, 12434–12437. [DOI: 10.1021/jacs.5b06492].
Self-Assembly of Russian Doll Concentric Porphyrin Nanorings.
Sophie A. L. Rousseaux, Juliane Q. Gong, Rene!e Haver, Barbara Odell, Tim D. W. Claridge, Laura M. Herz, and Harry L. Anderson
J. Am. Chem. Soc., 2015, 137, 12713-12718. [DOI: 10.1021/jacs.5b07956].
Cation-π interactions contribute to substrate recognition in γ-butyrobetaine hydroxylase catalysis.
Jos J. A. G. Kamps, Amjad Khan, Hwanho Choi, Robert K. Lesniak, Jürgen Brem, Anna M. Rydzik, Michael A. McDonough, Christopher J. Schofield, Timothy D. W. Claridge and Jasmin Mecinović
Chem. Eur. J., 2015, 22, 1270-1276 [DOI: 10.1002/chem.201503761]
Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans.
Richard J. Hopkinson , Ivanhoe K. H. Leung, Tristan J. Smart, Nathan R. Rose, Luc Henry, Timothy D. W. Claridge, Christopher J. Schofield
PLoS ONE, 10(12):e0145085 [DOI: 10.1371/journal.pone.0145085]
H2 activation by a highly electron-deficient aralkylated organoborane
Hill, Peter J.; Herrington, Thomas J.; Rees, Nicholas H.; White, Andrew J. P.; Ashley, Andrew E.
Dalton Transactions, 2015, 44, 8984-8992 [DOI: 10.1039/C5DT00821B]
Stoichiometric and Catalytic Solid-Gas Reactivity of Rhodium Bis-phosphine Complexes
Pike, Sebastian D.; Kramer, Tobias; Rees, Nicholas H.; MacGregor, Stuart. A.; Weller, Andrew S.
Organometallics, 2015, 34, 1487-1497 [DOI: 10.1021/om5013133]
Solid-State Synthesis and Characterization of σ-Alkane Complexes, [Rh(L2)(η2,η2-C7H12)][BArF4] (L2 = Bidentate Chelating Phosphine)
Pike, Sebastian D.; Chadwick, F. Mark; Rees, Nicholas H.; Scott, Mark P.; Weller, Andrew S.; Kramer, Tobias; Macgregor, Stuart A
Journal of the American Chemical Society, 137, 820-833 [DOI: 10.1021/ja510437p].
Fluoromethylated derivatives of carnitine biosynthesis intermediates – synthesis and applications.
Anna M. Rydzik, Ivanhoe K. H. Leung, Armin Thalhammer, Grazyna T. Kochan, Timothy D. W. Claridge and Christopher J. Schofield
Chem. Commun., 2014, 50, 1175-1177 [DOI: 10.1039/c3cc47581f]
Synthetic control of retinal photochemistry and photophysics in solution.
Giovanni Bassolino, Tina Sovdat, Matz Liebel, Christoph Schnedermann, Barbara Odell, Timothy D.W. Claridge, Philipp Kukura, Stephen P. Fletcher
J. Am. Chem. Soc., 2014, 136, 2650-2658. [DOI: 10.1021/ja4121814]
Monitoring conformational changes in the NDM-1 Metallo-β-lactamase by 19F NMR
Anna M. Rydzik, Jürgen Brem, Sander S. van Berkel, Inga Pfeffer, Anne Makena, Timothy D. W. Claridge, Christopher J. Schofield
Angew. Chem. Int. Ed. Engl., 2014, 53, 3129-3133. [DOI: 10.1002/anie.201310866]
Non-Enzymatic Chemistry Enables 2-Hydroxyglutarate Mediated Activation of 2-Oxoglutarate Oxygenases.
Hanna Tarhonskaya, Anna M. Rydzik, Ivanhoe K. H. Leung, Nikita D. Loik, Mun Chiang Chan, Akane Kawamura, James S. O. McCullagh, Timothy D. W. Claridge, Emily Flashman and Christopher J. Schofield
Nat. Commun., 2014, 5, 3423 [DOI:10.1038/ncomms4423]
Studies on Deacetoxycephalosporin C Synthase Support a Consensus Mechanism for 2-Oxoglutarate Dependent Oxygenases
Hanna Tarhonskaya, Andrea Szöllössi, Ivanhoe K. H. Leung, Jacob T. Bush, Luc Henry, Rasheduzzaman Chowdhury, Aman Iqbal, Timothy D. W. Claridge, Christopher J. Schofield, and Emily Flashman
Biochemistry, 2014, 53, 2483−2493. [DOI: 10.1021/bi500086p].
Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase.
Anna M. Rydzik, Ivanhoe K. H. Leung, Grazyna T. Kochan, Nikita D. Loik, Luc Henry, Michael A. McDonough, Timothy D. W. Claridge and Christopher J. Schofield
Org. Biomol. Chem, 2014, 12, 6354–6358. [DOI: 10.1039/C4OB01167H]
Physical autocatalysis driven by a bond-forming thiol-ene reaction
Bissette, Andrew J., Odell, Barbara ;Fletcher, Stephen P.
Nature Communications (2014), 5, 4607
Conformational studies on substituted ε-caprolactams by X-ray crystallography and NMR spectroscopy
Gruber, Tobias; Thompson, Amber L.; Odell, Barbara; Bombicz, Petra; Schofield, Christopher J.
New Journal of Chemistry (2014), 38(12), 5905-5917
Oxygenase-Catalysed Desymmetrisation of N,N-Dialkyl Piperidine-4-carboxylic acids.
Anna M. Rydzik, Ivanhoe K. H. Leung, Grazyna T. Kochan, Michael A. McDonough, Timothy D. W. Claridge and Christopher J. Schofield
Angew. Chem. Int. Ed. 2014, 53, 10925 –10927 [DOI: 10.1002/anie.201406125]
Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation.
John S. Scotti, Ivanhoe K. H. Leung, Wei Ge, Michael A. Bentley, Jordi Paps, Holger B. Kramer, Joongoo Lee, WeiShen Aik, Hwanho Choi, Steinar M. Paulsen, Lesley A. H. Bowman, Nikita D. Loik, Shoichiro Horita, Chia-hua Ho, Nadia J. Kershaw, Christoph M. Tang, Timothy D. W. Claridge, Gail M. Preston, Michael A. McDonough, and Christopher J. Schofield
Proc. Natl. Acad. Sci., 2014, 111, 13331-13336. [DOI:10.1073/pnas.1409916111].
A type-II biomarker for differentiating relapsing remitting from secondary progressive multiple sclerosis.
A.M. Dickens, J.R. Larkin, J. L. Griffin, A. Cavey, L. Matthews, M.R. Turner, G.K. Wilcock, B.G. Davis, T.D.W. Claridge, J. Palace, D.C. Anthony, N.R. Sibson
Neurology, 2014, 83, 1492-1499. [DOI: 10.1212/WNL.0000000000000905].
Rhodanine Hydrolysis Leads to Potent Thioenolate Mediated Metallo-β-Lactamase inhibition.
Jürgen Brem, Sander S. van Berkel, WeiShen Aik, Anna Rydzik, Matthew B. Avison, Ilaria Pettinati, Klaus-Daniel Umland, Akane Kawamura, James Spencer, Timothy D.W. Claridge, Michael A. McDonough, and Christopher J. Schofield
Nature Chem. 2014, 6, 1084-1090. [DOI:10.1038/nchem.2110]
Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen.
Hanna Tarhonskaya, Rasheduzzaman Chowdhury, Ivanhoe K. H. Leung, Nikita D. Loik, James S. O. McCullagh, Timothy D. W. Claridge, Christopher J. Schofield and Emily Flashman
Biochem. J., 2014, 463, 363–372. [DOI:10.1042/BJ20140779]
Toward the Understanding of Modulation in Molecular Materials: Barluenga's Reagent and its Analogues.
Kim, Yejin; Mckinley, Emma J.; Christensen, Kirsten E.; Rees, Nicholas H.; Thompson, Amber L
Crystal Growth & Design, 2014, 14, 6294-6301. [DOI: 10.1021/cg500983s]
Rationalizing and Disrupting Fluxional Processes in Agostically Stabilized 14-Electron Alkyliridium Hydride Complexes.
Phillips, Nicholas; Treasure, Lucinda; Rees, Nicholas H.; Tirfoin, Remi; McGrady, John E.; Aldridge, Simon
European Journal of Inorganic Chemistry, 2014, 28, 4877-4885 [DOI: 10.1002/ejic.201402516].
Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase.
Refaat B. Hamed, Luc Henry, J. Ruben Gomez-Castellanos, Amina Asghar, Jürgen Brem, Timothy D. W. Claridge and Christopher J. Schofield
Org. Biomol. Chem., 2013, 11, 8191-8196.
Solution phase structures of enantiopure and racemic lithium N-benzyl-N-(α-methylbenzyl)amide in THF: low temperature 6Li and 15N NMR spectroscopic studies.
Timothy D. W. Claridge, Stephen G. Davies, Dennis Kruchinin, Barbara Odell, Paul M. Roberts, Angela J. Russell, James E. Thomson, Steven M. Toms.
Tetrahedron: Asymmetry, 2013, 24, 947–952.
A Discrete Three-Layer Stack Aggregate of a Linear Porphyrin Tetramer: Solution-Phase Structure Elucidation by NMR and X-Ray Scattering.
Marie Hutin, Johannes K. Sprafke, Barbara Odell, Harry L. Anderson and Tim D. W. Claridge.
J. Am. Chem. Soc., 2013, 135, 12798−12807.
Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3.
Sander S. van Berkel, Joanne E. Nettleship, Ivanhoe K. H. Leung, Jürgen Brem, Hwanho Choi, David I. Stuart, Timothy D. W. Claridge, Michael A. McDonough, Raymond J. Owens, Jingshan Ren, Christopher J. Schofield.
ACS Chem. Biol., 2013, 8, 2112-2116.
Chiral Recognition in Contact Ion-pairs; Observation, Characterization and Analysis.
J. A. Raskatov, A. L. Thompson, A. R. Cowley, T. D. W. Claridge and J. M. Brown.
Chem. Sci., 2013, 4, 3140 – 3147.
Multielement NMR Studies of the Liquid-Liquid Phase Separation and the Metal-to-Nonmetal Transition in Fluid Lithium- and Sodium-Ammonia Solutions
Lodge, Matthew T. J. H.; Cullen, P.; Rees, Nicholas H.; Spencer, Neil; Maeda, Kiminori; Harmer, Jeffrey R.; Jones, Martin O.; Edwards, Peter P.
Journal of Physical Chemistry B 2013, 117, 13322-13334.
Local probes show that framework modification in zeolites occurs on ammonium exchange without calcination
Sartbaeva, Asel; Rees, Nicholas H.; Edwards, Peter P.; Ramirez-Cuesta, Anibal J.; Barney, Emma
Journal of Materials Chemistry A: Materials for Energy and Sustainability 2013, 1, 7415-7421.
Is JmjC Oxygenase Catalysis Limited to Demethylation?
Richard J. Hopkinson, Louise J. Walport, Martin Münzel, Nathan R. Rose, Tristan J. Smart, Akane Kawamura, Timothy D. W. Claridge and Christopher J. Schofield.
Angew. Chem. Int. Ed. Engl., 2013, 52, 7709-7713.
A phthalate family oxygenase reductase supports terpene alcohol oxidation by CYP238A1 from Pseudomonas putida KT2440
Bell, Stephen Graham; French, Laura; Rees, Nicholas Huw; Cheng, Sophia Shuyi; Preston, Gail; Wong, Luet-Lok
Biotechnology and Applied Biochemistry 2013, 60, 9-17.
Substrate Selectivity Analyses of Factor Inhibiting Hypoxia-Inducible Factor
Ming Yang, Adam P. Hardy, Rasheduzzaman Chowdhury, Nikita D. Loik, John S. Scotti, James S. O. McCullagh, Timothy D. W. Claridge, Michael A. McDonough, Wei Ge and Christopher J. Schofield.
Angew. Chem. Int. Ed. Engl., 2013, 52,1700-1704.
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors
Ivanhoe K. H. Leung, Marina Demetriades, Adam P. Hardy, Clarisse Lejeune, Tristan J. Smart, Andrea Szöllössi, Akane Kawamura, Christopher J. Schofield, Timothy D. W. Claridge.
J. Med. Chem., 2013, 56, 547-555.
Acceleration of the Eschenmoser coupling reaction by sonication: efficient synthesis of enaminones
Naga Durgarao Koduri, Bethany Hileman, Justin D. Cox, Halee Scott, Phuong Hoang, Alexa Robbins, Kyle Bowers, Lemma Tsebaot, Kun Miao, Maria Castaneda, Michael Coffin, Guan Wei, Tim D. W. Claridge, Kenneth P. Roberts and Syed Raziullah Hussaini.
RSC Adv., 2013, 3, 181-188.
Oxygenase Catalysed Ribosome Hydroxylation Occurs in Prokaryotes and Humans
Wei Ge, Alexander Wolf, Tianshu Feng, Chia-hua Ho, Rok Sekirnik, Adam Zayer, Nicolas Granatino, Matthew E. Cockman, Christoph Loenarz, Nikita D. Loik, Adam P. Hardy, Timothy D.W. Claridge, Refaat B. Hamed, Rasheduzzaman Chowdhury, Lingzhi Gong, Carol V. Robinson, David C. Trudgian, Miao Jiang, Mukram M. Mackeen, James S. Mccullagh, Yuliya Gordiyenko, Armin Thalhammer, Atsushi Yamamoto, Ming Yang, Phebee Liu-Yi, Zhihong Zhang, Marion Schmidt-Zachmann, Benedikt M. Kessler, Peter J. Ratcliffe, Gail M. Preston, Mathew L. Coleman, Christopher J. Schofield.
Nature Chem. Biol., 2012, 8, 960-962.
Conformational analysis of fluorinated pyrrolidines using 19F-1H scalar couplings and heteronuclear nOes
Lorraine E. Combettes, Philip Clausen-Thue, Mike King, Barbara Odell, Amber L. Thompson, Véronique Gouverneur, and Tim D. W. Claridge.
Chem. Eur. J, 2012, 18, 13133-13141.
Synthesis of 3-Fluoropyrrolidines and 4-Fluoropyrrolidin-2-ones from Allylic Fluorides
Lorraine E. Combettes, Marie Schuler, Rakesh Patel, Baltasar Bonillo, Barbara Odell, Amber L. Thompson, Tim D. W. Claridge, and Véronique Gouverneur.
Chem. Eur. J, 2012, 18, 13126-13132.
Ammonium-Directed Olefinic Epoxidation: Kinetic and Mechanistic Insights
Méabh B. Brennan, Timothy D. W. Claridge, Richard G. Compton, Stephen G. Davies, Ai M. Fletcher, Martin C. Henstridge, David S. Hewings, Wataru Kurosawa, James A. Lee, Paul M. Roberts, Anne K. Schoonen, and James E. Thomson.
J. Org. Chem, 2012, 77, 7241-7261.
γ-Butyrobetaine Hydroxylase Catalyses a Stevens Type Rearrangement
Luc Henry, Ivanhoe K. H. Leung, Timothy D. W. Claridge, Christopher J. Schofield.
Biorg. Med. Chem. Lett., 2012, 22, 4975-4978.
Development and application of a fluoride detection based fluorescence assay for γ-butyrobetaine hydroxylase
Anna M. Rydzik, Ivanhoe K. H. Leung, Grazyna T. Kochan, Armin Thalhammer, Udo Oppermann, Timothy D. W. Claridge and Christopher J. Schofield.
ChemBioChem, 2012, 13, 1559–1563.
Fluorescent Charge-Assisted Halogen-Bonding Macrocyclic Halo-Imidazolium Receptors for Anion Recognition and Sensing in Aqueous Media
Fabiola Zapata, Antonio Caballero, Nicholas G. White, Tim D. W. Claridge, Paulo J. Costa, Vitor Felix and Paul D. Beer.
J. Am. Chem. Soc., 2012, 134, 11533-11541.
Sterically Encumbered Iridium Bis(N-
Phillips, Nicholas; Rowles, Johnny; Kelly, Michael J.; Riddlestone, Ian; Rees, Nicholas H.; Dervisi, Athanasia; Fallis, Ian A.; Aldridge, Simon
Organometallics, 2012, 31, 8075-8078.
Dynamic Chemistry Employing Boronic Acids / Boronate Esters Leads to Potent Oxygenase Inhibitors
Marina Demetriades, Ivanhoe K. H. Leung, Rasheduzzaman Chowdhury, Mun Chiang Chan, Kar Kheng Yeoh,Ya-Min Tian, Timothy D.W Claridge, Peter J. Ratcliffe, Esther C. Y. Woon, Christopher J. Schofield.
Angew. Chem. Int. Ed. Engl., 2012, 51, 6672-6675.
Observation of a Transient Intermediate in Soai's Asymmetric Autocatalysis: Insights from 1H NMR Turnover in Real Time
Gehring, Timo; Quaranta, Michela; Odell, Barbara; Blackmond, Donna G.; Brown, John M.
Angew. Chem. Int. Ed. Engl., 2012, 51, 9539-9542
Conformational Effects in Sugar Ions: Spectroscopic Investigations in the Gas Phase and in Solution
Ram Sagar, Svemir Rudić, David P. Gamblin, Eoin M. Scanlan, Timothy D. Vaden, Barbara Odell, Timothy D.W. Claridge, John P. Simons and Benjamin G. Davis
Chem. Sci., 2012, 3, 2307-2313
Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams
Refaat B. Hamed, Luc Henry, J. Ruben Gomez-Castellanos, Jasmin Mecinović, Christian Ducho, John L. Sorensen, Timothy D. W. Claridge, and Christopher J. Schofield
J. Am. Chem. Soc., 2012, 134, 471-479
Factor-Inhibiting Hypoxia-Inducible Factor (FIH) Catalyses the Post-translational Hydroxylation of Histidinyl Residues within Ankyrin Repeat Domains
Ming Yang, Rasheduzzaman Chowdhury, Wei Ge, Refaat B. Hamed, Michael A. McDonough, Timothy D. W. Claridge, Benedikt M. Kessler, Matthew E. Cockman, Peter J. Ratcliffe and Christopher J. Schofield
FEBS Lett., (2011), 278, 1086-1097
Dimeric Self-Association of an Isophthalamide Macrocycle in Solution and the Solid State
Christopher J. Serpell, Owen Thomas, Barbara Odell, Timothy D. W. Claridge, Ricky Chall, Amber L. Thompson, and Paul D. Beer
Cryst. Eng. Comm., (2011), 13, 4586-4591
Separating electrophilicity and lewis acidity: the synthesis, characterization, and electrochemistry of the electron deficient tris(aryl)
Ashley, Andrew E.; Herrington, Thomas J.; Wildgoose, Gregory G.; Zaher, Hasna; Thompson, Amber L.; Rees, Nicholas H.; Kramer, Tobias; O'Hare, Dermot
J. Am. Chem. Soc. (2011), 133, 14727-14740
All-or-Nothing Cooperative Self-Assembly of an Annulene Sandwich
Johannes K. Sprafke, Barbara Odell, Timothy D. W. Claridge and Harry L. Anderson
Angew. Chem. Int. Ed. Engl., (2011), 50, 5572-5575
An approach to enzyme inhibition employing reversible boronate ester formation
Ivanhoe K. H. Leung, Tom Brown Jr, Christopher J. Schofield, Timothy D. W. Claridge.
Med. Chem. Comm., (2011), 2, 390-395
Dearomatisation of o-
Whitehouse, Christopher J. C.; Rees, Nicholas H.; Bell, Stephen G.; Wong, Luet-Lok
Chem. Eur. J. (2011), 17, 6862-6868
Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases
Refaat B. Hamed, J. Ruben Gomez-Castellanos, Armin Thalhammer, Daniel Harding, Christian Ducho, Timothy D. W. Claridge, and Christopher J. Schofield.
Nature Chem., (2011), 3, 365-371
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
Rasheduzzaman Chowdhury, Kar Kheng Yeoh, Ya-Min Tian, Lars Hillringhaus, Eleanor A. Bagg, Nathan R. Rose, Ivanhoe K.H. Leung, Xuan S. Li, Esther C.Y. Woon, Ming Yang, Michael A.McDonough, Oliver N. King, Ian J. Clifton, Robert J. Klose, Timothy D.W. Claridge, Peter J. Ratcliffe, Christopher J. Schofield & Akane Kawamura
EMBO Reports, (2011), 12, 463-469
New insights into the intercalation chemistry of Al(OH)
Williams, Gareth R.; Moorhouse, Saul J.; Prior, Timothy J.; Fogg, Andrew M.; Rees, Nicholas H.; O'Hare, Dermot
Dalton Trans. (2011), 40, 6012-6022
The bis(hydrogenheptaphosphide)iron(II) dianion: a Zintl ion analogue of ferrocene?
Caroline M. Knapp, Joseph S. Large, Nicholas H. Rees and Jose M. Goicoechea
Chem. Commun., (2011), 47, 4111-4113
{Rh(PiBu3)
Woolf, Anthony; Chaplin, Adrian B.; McGrady, John E.; Alibadi, Muhsen A. M.; Rees, Nicholas; Draper, Sylvia; Murphy, Frances; Weller, Andrew S
Eur. J. Inorg. Chem. (2011), 10, 1614-1625
A systematic study of the solid state and solution phase conformational preferences of b-peptides derived from C(3)-alkyl substituted transpentacin derivatives
Elin Abraham, Timothy D.W. Claridge, Stephen G. Davies , Barbara Odell, Paul M. Roberts, Angela J. Russell, Andrew D. Smith, Lorna J. Smith, Helen R. Storr, Miles J. Sweet, Amber L. Thompson, James E. Thomson, George E. Tranter, David J. Watkin
Tetrahedron: Asymmetry, (2011), 22, 69-100
Asparagine and aspartate hydroxylation of the cytoskeletal Ankyrin family is catalysed by Factor-Inhibiting Hypoxia-Inducible Factor
Ming Yang, Wei Ge, Rasheduzzaman Chowdhury, Timothy D. W. Claridge, Holger B. Kramer, Bernhard Schmierer, Michael A. McDonough, Lingzhi Gong, Benedikt M. Kessler, Peter J. Ratcliffe, Mathew L. Coleman, and Christopher J. Schofield
J. Biol. Chem., (2011), 286, 7648-7660
The 2-Oxoglutarate Dependent Oxygenase JMJD6 Catalyses Oxidation of Lysine Residues to give 5S-Hydroxylysine Residues
Monica Mantri, Nikita D. Loik, Refaat B. Hamed, Timothy D. W. Claridge, James S. O. McCullagh, Christopher J. Schofield
ChemBioChem, (2011), 12, 531-534.
Tuning the cavity of cyclodextrins: altered sugar adaptors in protein pores
Wen-Wu Li, Timothy D.W. Claridge, Qiuhong Li, Mark R. Wormald, Benjamin G. Davis and Hagan Bayley
J. Am. Chem. Soc., (2011), 133, 1987-2001
Structural Analysis of CYP101C1 from Novosphingobium aromaticivorans DSM12444
Ma, Ming; Bell, Stephen G.; Yang, Wen; Hao, Yiming; Rees, Nicholas H.; Bartlam, Mark; Zhou, Weihong; Wong, Luet-Lok; Rao, Zihe
ChemBioChem, (2011), 12, 88-99
A versatile salt-
Knapp, Caroline M.; Large, Joseph S.; Rees, Nicholas H.; Goicoechea, Jose M.
Dalton Trans., (2011), 40, 735-745
Vernier Templating and Synthesis of a 12-Porphyrin Nano-ring
Melanie C. O’Sullivan, Johannes K. Sprafke, Dmitry V. Kondratuk, Corentin Rinfray, Timothy D. W. Claridge, Alex Saywell, Matthew O. Blunt, James N. O’Shea, Peter H. Beton, Marc Malfois & Harry L. Anderson.
Nature, (2011), 469, 72-75.
Structural and Mechanistic Studies on g-Butyrobetaine Hydroxylase
Ivanhoe K.H. Leung, Tobias J. Krojer, Grazyna T. Kochan , Luc Henry, Frank von Delft, Timothy D. W. Claridge, Udo Oppermann, Michael A. McDonough, and Christopher J. Schofield.
Chemistry & Biology, (2010), 17, 1316-1324
Michela Quaranta, Timo Gehring, Barbara Odell, John M. Brown, and Donna G. Blackmond,
J. Am. Chem. Soc., (2010), 132, 15104-15107
Studies on the reaction of glutathione and formaldehyde using NMR
Hopkinson, Richard J., Barlow, Pippa S.; Schofield, Christopher. J.; Claridge, Timothy D. W.
Organic & Biomolecular Chemistry, (2010), 8(21), 4915-4920.
A systematic study of the solid state and solution phase conformational preferences of β-peptides derived from transpentacin
Abraham, Elin; Bailey, Callum W.; Claridge, Timothy D. W.; Davies, Stephen G.; Ling, Kenneth B.; Odell, Barbara; Rees, Thomas L.; Roberts, Paul M.; Russell, Angela J.; Smith, Andrew D.; et al
Tetrahedron: Asymmetry (2010), 21(13-14), 1797-1815.
Carboxymethylproline synthase catalyzed syntheses of functionalized N-heterocycles
Hamed, Refaat B.; Mecinovic, Jasmin; Ducho, Christian; Claridge, Timothy D. W.; Schofield, Christopher J.
Chemical Communications (2010), 46(9), 1413-1415.
Group epitope mapping considering relaxation of the ligand (GEM-CRL): Including longitudinal relaxation rates in the analysis of saturation transfer difference (STD) experiments
Kemper, Sebastian; Patel, Mitul K.; Errey, James C.; Davis, Benjamin G.; Jones, Jonathan A.; Claridge, Timothy D. W.
Journal of Magnetic Resonance (2010), 203(1), 1-10.
Monitoring the Activity of 2-Oxoglutarate Dependent Histone Demethylases by NMR Spectroscopy: Direct Observation of Formaldehyde
Hopkinson, Richard J.; Hamed, Refaat B.; Rose, Nathan R.; Claridge, Timothy D. W.; Schofield, Christopher J.
ChemBioChem (2010), 11(4), 506-510.
Structure and reactivity of bicyclic methylene aziridines prepared by intramolecular aziridination of allenes
Robertson, Jeremy; Feast, George C.; White, Louise V.; Steadman, Victoria A.; Claridge, Timothy D. W.
Organic & Biomolecular Chemistry (2010), 8(13), 3060-3063.
Using NMR Solvent Water Relaxation to Investigate Metalloenzyme-Ligand Binding Interactions
Leung, Ivanhoe K. H.; Flashman, Emily; Yeoh, Kar Kheng; Schofield, Christopher J.; Claridge, Timothy D. W.
Journal of Medicinal Chemistry (2010), 53(2), 867-875.
TOCSY
Claridge, Timothy D. W., in Multidimensional NMR Methods for the Solution State, (Chapter 16), Eds. G. A. Morris and J. W. Emsley, (Wiley).
- The intercalation of bicyclic and tricyclic carboxylates into layered double hydroxides
Khan, Aamir I.; Williams, Gareth R.; Hu, Gang; Rees, Nicholas H.; O'Hare, Dermot
Journal of Solid State Chemistry, (2010), 183, 2877-2885
Sr3Co2O4.33H0.84: An Extended Transition Metal Oxide-
Helps, Rebecca M.; Rees, Nicholas H.; Hayward, Michael A
Inorganic Chemistry, (2010), 49, 11062-11068
A cytochrome P450 class I electron transfer system from Novosphingobium aromaticivorans
Bell Stephen G; Dale Alison; Rees Nicholas H; Wong Luet-Lok
Applied microbiology and biotechnology, (2010), 86, 163-75.
Reactivity of the Latent 12-Electron Fragment [Rh(PiBu3)2]+ with Aryl Bromides: Aryl-Br and Phosphine Ligand C-H Activation
Townsend, Nell S.; Chaplin, Adrian B.; Abu Naser, M.; Thompson, Amber L.; Rees, Nicholas H.; MacGregor, Stuart A.; Weller, Andrew S.
Chemistry--A European Journal (2010), 16(28), 8376-8389.
Reactivity studies of group 15 Zintl ions towards homoleptic post-transition metal organometallics: a bottom-up' approach to bimetallic molecular clusters
Knapp, Caroline; Zhou, Binbin; Denning, Mark S.; Rees, Nicholas H.; Goicoechea, Jose M.
Dalton Transactions, (2010), 39, 426-436.
High-Resolution NMR Techniques in Organic Chemistry (2nd Edn)
Claridge, Timothy D. W., Elsevier.
TOCSY
Claridge, Timothy D. W., in Encyclopedia of Magnetic Resonance, Eds R. K. Harris and R. E. Wasylishen, (Wiley)
A C-linked Glycomimetic in the Gas Phase and in Solution: Synthesis and Conformation of the Disaccharide Manα(1,6)-C-ManαOPh
Drouin, Ludovic; Stanca-Kaposta, E. Cristina; Saundh, Priptal; Fairbanks, Antony J.; Kemper, Sebastian; Claridge, Timothy D. W.; Simons, John P.
Chemistry--A European Journal (2009), 15(16), 4057-4069, S4057/1-S4057/37.
Anatomy of a Simple Acyl Intermediate in Enzyme Catalysis: Combined Biophysical and Modeling Studies on Ornithine Acetyl Transferase
Iqbal, Aman; Clifton, Ian J.; Bagonis, Maria; Kershaw, Nadia J.; Domene, Carmen; Claridge, Timothy D. W.; Wharton, Christopher W.; Schofield, Christopher J.
Journal of the American Chemical Society (2009), 131(2), 749-757.
Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline
Hamed, Refaat B.; Batchelar, Edward T.; Mecinovic, Jasmin; Claridge, Timothy D. W.; Schofield, Christopher J.
ChemBioChem (2009), 10(2), 246-250.
Saturation transfer difference NMR reveals functionally essential kinetic differences for a sugar-binding repressor protein
Perez-Victoria, Ignacio; Kemper, Sebastian; Patel, Mitul K.; Edwards, John M.; Errey, James C.; Primavesi, Lucia F.; Paul, Matthew J.; Claridge, Timothy D. W.; Davis, Benjamin G.
Chemical Communications (2009), (39), 5862-5864.
Sulfate anion templated synthesis of a triply interlocked capsule
Li, Yitong; Mullen, Kathleen M.; Claridge, Tim D. W.; Costa, Paulo J.; Felix, Vitor; Beer, Paul D.
Chemical Communications (2009), (46), 7134-7136.
Synthesis of regio- and stereoselectively deuterium-labeled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis
By Ducho, Christian; Hamed, Refaat B.; Batchelar, Edward T.; Sorensen, John L.; Odell, Barbara; Schofield, Christopher J.
Organic & Biomolecular Chemistry (2009), 7(13), 2770-2779.
Tetrameric iridium hydride-rich clusters formed under hydrogenation conditions
Xu, Yingjian; Celik, Mehmet A.; Thompson, Amber L.; Cai, Hairong; Yurtsever, Mine; Odell, Barbara; Green, Jennifer C.; Mingos, D. Michael P.; Brown, John M.
Angewandte Chemie, International Edition (2009), 48(3), 582-585.
β-Agostic Silylamido and Silyl-Hydrido Compounds of Molybdenum and Tungsten
Ignatov, Stanislav K.; Khalimon, Andrey Y.; Rees, Nicholas H.; Razuvaev, Alexei G.; Mountford, Philip; Nikonov, Georgii I.
Inorganic Chemistry (2009), 48(20), 9605-9622.
A study of phosphate absorption by magnesium iron hydroxycarbonate
Du, Yi; Rees, Nicholas; O'Hare, Dermot
Dalton Transactions (2009), (39), 8197-8202.
Beta-agostic silylamido and silyl-hydrido compounds of molybdenum and tungsten
Ignatov Stanislav K; Khalimon Andrey Y; Rees Nicholas H; Razuvaev Alexei G; Mountford Philip; Nikonov Georgii I
Inorganic chemistry (2009), 48(20), 9605-22.
Incorporation of phosphorus oxyacids into layered double hydroxides
By Williams, Gareth R.; Rees, Nicholas H.; O'Hare, Dermot
Solid State Sciences (2009), 11(7), 1229-1238.
